![]() ![]() As a model, we review skin wound healing in chronological order, and when possible, we use that overview as a framework to point out possible mechanisms of how damaged tissues can restore their original structure. Thoughts like this have motivated us to assemble more than just a factographic synopsis on tissue regeneration. Thus, there is a requirement for more than only the presence of the entire genetic code in somatic cells for regenerative abilities. On the other hand, it is possible to clone mammals from somatic cells, showing that a complete developmental program is intact in a wounded sheep's tail the same way it is in a lizard. Selected developmental, surgical, and tissue engineering aspects are presented and discussed in the light of recent findings in the field.When a sheep loses its tail, it cannot regenerate it in the manner of lizards. ![]() We support such an idea by referring to an extremely fragmented literature base, trying to synthesize a broad picture of important principles of how tissues and organs may store information about their own structure for the purposes of regeneration. This article postulates the existence of tissue structural memory as a complex distributed homeostatic mechanism. ![]() ![]() When a sheep loses its tail, it cannot regenerate it in the manner of lizards. ![]()
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